The invention provides a method for preparing perfluoro-olefine ether from an acid-sensitive group-containing compound. The method comprises the following steps: carrying out the reaction between single-substituted glycols compound containing an MOM protecting group (CH3OCH2-) which is sensitive to acid, and hexafluoropropylene oxide; forming a part of fluoro ester through an ester exchange reaction; directly fluorizing the acid-sensitive group-containing compound with fluorine; and subjecting to cracking to obtain the perfluoro-olefine ether. The method is characterized in that the fluorization process adopts the gradual temperature rise method ( minus 20 DEG C to 15 DEG C), and the corresponding reaction temperature condition is applied according to the different requirements for the stability of molecular structures with different fluorization extents in different stages; and in the different temperature stages, sodium fluoride is added intermittently so as to effectively slow down the decomposition of the acid-sensitive group in the raw material in an strong acid environment.