The invention provides an intraductal intelligent plugging device, which comprises a main drive cylinder, a pressure head, an actuator disk, an extrusion bowl, at least two locking slide blocks, a ring spacer and a signal transceiver device, wherein, the main drive cylinder is provided with a cylinder body, a piston and a piston rod connected with the piston; the pressure head is connected with the end of the piston rod far away from piston; the actuator disk is connected with the cylinder body; the extrusion bowl is arranged between the pressure head and the actuator disk in a sliding way, and the extrusion bowl is provided with a tilted conical slide surface and an extrusion end face; each of the two locking slide blocks is connected with a subsidiary drive cylinder, and each subsidiarydrive cylinder is fixed on the actuator disk; the bottom surface of the locking slide block is matched with the conical slide surface of the extrusion bowl in a sliding way, and the locking slide block performs the locking function in a radial expansion way when sliding upward along the conical slide surface; the ring spacer is arranged between the pressure head and the actuator disk, and is extruded by the extrusion end face of the extrusion bowl to perform the plugging function in a radial expansion way; the signal transceiver device is connected with the intraductal intelligent plugging device to receive control signals to drive the main drive cylinder.