The invention discloses a method for producing MTBE (methyl tert-butyl ether) from C4 and methanol. The method is characterized by comprising the following: (1) a step of raw materials pretreatment, which is to fully mix the C4 containing isobutene and the methanol through a static mixer, then to heat up raw materials to the temperature of between 30 and 60 DEG C through a raw material preheater,and to perform etherification reaction initially in a purifier; and (2) a step of reaction and product separation, during which, the mixed raw materials from the purifier are cooled to the temperature of between 30 DEG C and 70 DEG C through a cooler and then enter a reactor to perform the etherification reaction, the mixture after reaction enters a catalytical distillation tower to carry out theetherification reaction, and the MTBE coming out from the bottom of the catalytical distillation tower is cooled by the cooler to obtain the MTBE finished product. The method effectively reduces the concentration of the isobutene of the raw materials in the reactor, better protects catalysts in the reactor, greatly prolongs the service cycle of the catalysts, and prolongs the equipment operation cycle simultaneously.