The invention relates to a drive method of a drive integrated circuit. The method comprises the following steps: the polarity of a driven grid line is monitored; when the polarity changes, the drive integrated circuit drives the grid line with a first mode signal; when the polarity does not change, the drive integrated circuit drives the grid line with a second mode signal; the drive current of the first mode signal is greater than that of the second mode signal. According to the polarity change circumstances of the driven grid line, the drive integrated circuit drives the grid line in different modes; as the drive current of the first mode signal is greater than that of the second mode signal, the method can minimize the charge delay deviation of the pixel electrodes between the grid lines, thus relieving the dark-line phenomenon.