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CN101406469B GAL3受体拮抗剂在治疗抑郁和/或焦虑中的应用及在这种方法中有用的化合物 失效 - 权利终止

GAL3受体拮抗剂在治疗抑郁和/或焦虑中的应用及在这种方法中有用的化合物
摘要：
本发明涉及嘧啶衍生物和吲哚酮衍生物，它们是GAL3受体的选择性拮抗剂。本发明提供了一种药物组合物，其包含一种治疗有效量的本发明化合物和一种药物可接受的载体。本发明还提供了一种药物组合物，其通过将一种治疗有效量的本发明化合物与一种药物可接受的载体组合而生产。本发明还提供了生产一种药物组合物的方法，所述药物组合物包含治疗有效量的本发明化合物和一种药物可接受的载体。本发明还提供了治疗患有抑郁症和/或焦虑症患者的方法，包括为患者施用治疗其抑郁症和/或焦虑症有效量的本发明化合物。本发明还提供了治疗患有抑郁症和/或焦虑症患者的方法，包括为患者施用一种组合物，该组合物包含一种药物可接受的载体和一种治疗有效量的GAL3受体拮抗剂。
摘要（英）：

This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and apharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.

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