The invention discloses a composition with the function of resisting inflammation and inhibiting bacteria. The composition comprises the following components in weight portion: 50 to 120 of baicalin, 3 to 20 portions of chlorogenic acid, 3 to 20 portions of orientoside and 1 to 10 portions of agnuside. The medicine is mainly used for treating various diseases caused by upper respiratory tract infection, such as influenza, pharyngitis, acute and chronic bronchitis, tonsillitis and pneumonia. The composition can be prepared into troches, powder injection, granules, soft capsules, hard capsules,oral liquid, buccal tablets or effervescent tablets.