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发明公开
CN101422447A 含有盐酸去氧肾上腺素的速溶性膜制剂及其制造方法 失效 - 权利终止

含有盐酸去氧肾上腺素的速溶性膜制剂及其制造方法
摘要：
本发明提供组合盐酸去氧肾上腺素、羟丙基纤维素和/或羟丙基甲基纤维素，能够在口腔内迅速溶解的膜制剂。本发明的含有盐酸去氧肾上腺素的速溶性膜制剂1的特征在于：具有树脂膜3、1层或2层以上的遮蔽层5、和1层或2层以上的含药物层7。遮蔽层5形成在树脂膜3上，含有可食性高分子物质、并且不含盐酸去氧肾上腺素。另外，含药物层7形成在遮蔽层5上，含有选自羟丙基纤维素和羟丙基甲基纤维素中的至少1种以及盐酸去氧肾上腺素。另外，本发明的含有盐酸去氧肾上腺素的速溶性膜制剂1，根据希望，也可以在含药物层7上具有含有可食性高分子物质、并且不含盐酸去氧肾上腺素的1层或2层以上的遮蔽层5。
摘要（英）：

The present invention provides a membrane preparation which is combined with phenylephrine hydrochloride, hydroxypropyl cellulose and/or hydroxypropyl methyl cellulose and can be quickly dissolved in oral cavity. The rapidly soluble membrane preparation 1 comprising phenylephrine hydrochloride 1 according to the invention is characterized by comprising a resin film 3, one layer or more than two layers of shielding layer 5, and one layer or more than two layers of medicine-containing layer 7. The shielding layer 5 is formed on the resin film 3 and comprises edible macromolecular substance and does not contain phenylephrine hydrochloride. Additionally the medicine-containing layer 7 is formed on the shielding layer 5 and comprises at least one component selected from hydroxypropyl cellulose and hydroxypropyl methyl cellulose. Furthermore the rapidly soluble membrane preparation 1 comprising phenylephrine hydrochloride 1 according to the invention can comprise one layer or more than two layers of shielding layer 5 that comprises edible macromolecular substance and does not contain phenylephrine hydrochloride according to expectation.

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