The invention relates to a single component water-based natural antibacterial inner wall coating and a production method thereof. The single component water-based natural antibacterial inner wall coating comprises the following components in weight portion: 334.5 portions of water, 15 portions of antifreeze agent, 1.5 portions of neutralizing agent, 2 portions of wetting agent, 6 portions of dispersing agent, 2 portions of foam killer, 200 portions of pigment, 25 portions of natural mineral antibacterial material, 100 portions of natural plant antibacterial material, 2 portions of preservative disinfectant, 300 portions of emulsion, and 10 portions of thickening agent. The coating has the advantages of good freezing and melting stability, low VOC content, convenient construction, even film forming, long service life, elasticity and capability of making up for fine cracks on the wall, and not only accords with the national industrial policy of energy conservation and environmental protection and recycling economy, but also explores a new direction for the development of the coating in future.