The invention relates to a safe handle with a lock. The safe handle is characterized by comprising a rotating handle (1) and a movable shaft (2) connected with a bolt-operating mechanism, wherein a lock structure which determines the rotating handle (1) and the movable shaft (2) to synchronously rotate or not is connected between the rotating handle (1) and the movable shaft (2); and the lock structure is inserted into the rotating handle (1). When the handle is locked, the rotating handle is separated from the movable shaft under the action of the lock structure; at the time, the rotating handle is in idle rotation, and can not drive action of the bolt-operating mechanism; and when the handle is unlocked, the rotating handle is connected with the movable shaft under the action of the lock structure, the rotating handle can drive the movable shaft at the time and the bolt-operating mechanism to act so as to realize door opening. Therefore, the structure plays a role in preventing lawless person from forcibly destroying the bolt-operating mechanism through hard turning or rotating the handle, so that the safe using the handle can further reinforce safety of the safe.