The invention relates to a cold-hot wet tissue box used for a vehicle, which is mounted at a blow-off nozzle of an on-vehicle air conditioner. The cold-hot wet tissue box comprises a wet tissue box body and a paper storage box, wherein, the paper storage box is positioned at the top end of the wet tissue box body. The cold-hot wet tissue box is characterized in that a water collecting box, a thermal conducting device, a water output control device and a wet tissue chamber are arranged in the wet tissue box body; the water collecting box is positioned at the lower end of the paper storage g device; the wet tissue chamber is arranged on the lower layer of the water collecting box; the water output control device is arranged at the water outlet of the water collecting box; one end of the thermal conducting device is jointed on the outer side of the water collecting box; and the other end of the thermal conducting device is connected to the blow-off nozzle of the on-vehicle air conditioner. Therefore, the invention can ensure that the water in the water collecting box thereof can be properly warned up by effectively adapting to the temperature of the cool air and the warm air blew offfrom the on-vehicle air conditioner, and the compressed paper towel can be wetted by the water with a certain temperature, thereby being convenient for the use of users, lifting the spirit of a driver, and ensuring driving safety.