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发明授权
CN101434962B 日本血吸虫中国大陆株酪氨酸激酶TK4保守区基因及其克隆表达方法和应用 失效 - 权利终止

日本血吸虫中国大陆株酪氨酸激酶TK4保守区基因及其克隆表达方法和应用
摘要：
本发明涉及日本血吸虫(中国大陆株)酪氨酸激酶TK4保守区(SjcTK4)基因的序列及其克隆表达方法和应用。本发明公开的SjcTK4基因具有序列1所示的核苷酸序列及编码相应的氨基酸序列。本发明还公开了SjcTK4基因在大肠杆菌中的表达方法。经制备纯化重组蛋白和DNA疫苗，免疫C57BL/6小鼠，发现本发明SjcTK4基因可用于制备防治日本血吸虫病的重组蛋白疫苗和DNA疫苗。
摘要（英）：

The invention relates to a SjcTK4 gene sequence in a tyrosine kinase TK4 conservative region of schistosoma japonicum (Chinese mainland strain), a clone expression method and application thereof. The SjcTK4 gene disclosed by the invention has the nucleotide sequence and the encoding-corresponding amino acid sequence that are shown in sequence 1. The invention further discloses the expression method of the SjcTK4 gene in Escherichia coli. By immunizing C57BL/6 mice with a purified recombinant protein vaccine and a DNA vaccine that are prepared, the SjcTK4 gene is shown to have the capability for preparing recombinant protein vaccines and DNA vaccines that can be used for preventing and curing schistosomiasis japonica.

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