The present invention relates to a product of Maillard reaction under ultrahigh pressure condition, and the application thereof in tobacco. The product is made by the following method: a sugar source with the mass ratio of 1:0.1-4 is mixed with amino acid and a reaction solvent, and then the mixture is pressured to 100-1000MPa at the pressure raising rate of 20-100MPa/min under a sealed condition and at the temperature of 25-100 DEG C for 20-100min, the reaction solvent mostly adopts water, polylol or the mixture of the water and the polylol with arbitrary proportion. The ultrahigh pressure technology is applied to the Maillard reaction to develop a novel product, thereby not only better decorating the smoke for flavouring, improving the fullness and mellow characteristic of the smoke, but also obviously improving the clearance rate of the reaction product on cigarette free radical, and exploring a practical approach for developing a 'Chinese style cigarette' with low harmfulness.