The invention discloses a method for producing 1,2-propylene glycol through biological mesicerin. The method is to fill a CuO-CeO2-SiO2 catalyst into a fixed bed reactor, to make glycerite and hydrogen flow into the reactor in the feeding mode, to control the reaction temperature to be between 170 and 200 DEG C and the reaction pressure to be between 1.0 and 5.0 MPa, and to realize hydrogenation production of the 1,2-propylene glycol through glycerol. The catalyst used by the method can maintain high selectivity on target products and high conversation rate of the glycerol within 500 hours.