The invention belongs to the novel technical field of medicaments, and specifically relates to pinaverium bromide sustained release tablets for treating irritable bowel syndrome, pains of symptomatic treatment and intestinal dysfunction, intestinal motility disorder and upset, spastic colon, pains of symptomatic treatment and dysfunction of biliary tract, peptic ulcer and biliary dyskinesia. The pinaverium bromide sustained release tablets is composed of pinaverium bromide, filling agent, sustained release agent, plasticizer, and anti-sticking agent with the weight ratio of 150 : (10-500) : (10-300) : (0-100) : (0-100), and prepared as pulp by ethanol, wherein the weight of the anti-sticking agent is 1% of that of the ethanol. The pinaverium bromide sustained release tablets maintains substantially stable blood concentration and longer action time, and has the advantages of less side effect and convenient administration.