The invention belongs to the novel technology field of the medicines and relates to a preparation and use of a ceftibuten dry suspension. The ceftibuten dry suspension is characterized by comprising, but not being limited by following excipients available by pharmacy: sucrose, mannitol, etc. as the loading agent; sodium chloride, aspartame, strawberry essence, etc. as the flavoring agent; carbomer, sodium carboxymethyl cellulose, sodium carboxy nethyl, etc. as the suspending agent. The ceftibuten dry suspension is used for treating: upper respiratory tract infection such as pharyngitis, antiaditis, scarlet fever, paranasal sinusitis, and otitis medium; lower respiratory tract infection such as acute bronchitis, acute attack of chronic bronchitis and pneumonia; urinary tract infection; enteritis and gastroenteritis.