The invention relates to development and application of anticoagulative compound synergistic rodenticide. The rodenticide mainly comprises bromadiolone and sodium dichlorophenolate, and is added with metronidazole, ethanol, glycerin and the like. The rodenticide can be prepared into liquid and powder. Bioassay shows that the rodenticide has good toxic effect for albino rats, mice, sewer rats, cricetulus tritons, microtus brandtis and apodemus agrariuses; the death ratio basically reaches 100 percent; and a large-are field test proves that prevention ratio for the sewer rats reaches more than 96 percent. When the bromadiolone content in the rodenticide is 0.002 percent, the control effect is better than or equal to the control effect of 0.005 percent of bromadiolone, so that cost is lowered greatly, environmental pollution is reduced, human and animal safety is ensured, and the national policy of energy saving and discharge reduction is firmly implemented. The rodenticide has the advantages of simple process and easy production, has special effect for antagonistic bandicoots, is fully suitable for control of various bandicoots, can be directly converted into productivity, and acquires economic benefit and social benefit as soon as possible.