The invention discloses a macro-micro dual-drive combined machining center which has a skid and rotation joint portion with thermal walking constraint, comprising a lathe body, upright posts, beams, X-axis parts, swing B-axis parts, rotation C-axis parts, a two-axes paralleling mechanism, a milling electro-spindle, Y-axis parts, Z-axis parts and a lapping-polishing electro-spindle, wherein the two-axes paralleling mechanism realizes the movement of a virtual W axis and a virtual V axis by adopting dual drive, a micro-drive actuator deforming guide way is adopted between a macro-micro dual-drive macro-motion table and a macro-micro dual-drive micro-drive table, the X-axis parts, the Y-axis parts and the two-axes paralleling mechanism movement pairs adopt combined slide seats which are combined by a cast iron working slide seat, a thermal walking constraint joint portion and a granite bearing slide seat, and the B-axis, the rotation C-axis and the two-axes paralleling mechanism rotationpairs adopt skid and rotation joint portion mechanisms. The combined machining center has a combined machining function that the five axes of X, B, C, V and W are interlinked so as to mill the complex moulding surfaces of hard parts at high speed and the five axes of X, B, C, Y and Z are interlinked so as to lap and polish the complex moulding surfaces of hard parts with high accuracy.