The invention discloses application of naringin in preparation of an anti-depression medicine. Dosage forms of the medicine are pharmaceutically acceptable dosage forms such as a tablet, a capsule, a solution, a suspension, an injection, a dripping injection and the like. A composition consists of the naringin as well as aglycon and secondary glucoside which are pharmaceutically acceptable and are generated through hydrolysis or enzymolysis, and is combined with pharmaceutical carriers to prepare various pharmaceutical dosage forms. The medicine has small toxicity, and overcomes the disadvantages of the prior anti-depression medicines such as excitation, constipation, anuresis, dizziness, hypersomnia, tremor and the like.