The invention relates to pyrrolidone derivatives of an HIV-1 inhibitor, a method for synthesizing the same and application thereof. The structural formula of the pyrrolidone derivatives is a formula I, wherein R<1>, R<2>, R<3> and R<4> are hydrogen, an aromatic radical, an alkyl radical or a heterocyclic radical; and R<5> is hydrogen, an alkyl radical and an aromatic radical. In the formula I, the four components can be easily synthesized from a compound (1), a compound(2), a compound(3) and a compound(4), and the yield is between 60 and 96 percent. The pyrrolidone derivatives or pharmaceutically acceptable salts thereof can be independently or combined with other medicines to prepare anti-AIDS medicines.