The invention relates to a dispersion compensation fiber with high dispersion coefficient used for carrying out dispersion compensation on a C wave band. The invention comprises a fiber core and a cladding; wherein, the fiber core comprises at least four fiber core sub-layers; the refringencey ranges of the four fiber core sub-layers from delta 1% to delta 4% are successively as follows: 1.80% to 2.20%, -1.20% to -0.95%, 0.40% to 0.70% and -0.01% to -0.15%; the ranges of the radiuses from r1 to r4 are successively as follows: 1.300 mu m to 1.520 mu m, 4.500 mu m to 5.200 mu m, 6.000 mu m to 7.500 mu m, and 10.000 mu m to 62.500 mu m. The invention has high negative dispersion and negative dispersion slope coefficient in an optical communication window on the C wave band; the dispersion compensation fiber is especially suitable for carrying out dispersion compensation to a high-speed DWDM system based on a G.655 fiber, thus upgrading the optical communication system working in the window on the C wave band; the optical fiber can be easily inserted in a communication link to meet the demand of the transportation of a high-speed and large-capacity system, and the miniaturization of the dispersion compensation module can be easily realized.