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发明授权
CN101513426B 大花鸡肉参酯甲(+)2-(1-羟基-4-氧代环己基)咖啡酸乙酯化合物及其在制备白三烯A4水解酶功能调节药物中的应用 失效 - 权利终止

大花鸡肉参酯甲(+)2-(1-羟基-4-氧代环己基)咖啡酸乙酯化合物及其在制备白三烯A4水解酶功能调节药物中的应用
摘要：
本发明公开了肉桂酸酯类化合物及其在制备白三烯A4水解酶功能调节药物中的应用，其结构通式如下：试验表明，该肉桂酸酯类化合物具有明显白三烯A4水解酶功能调节剂作用，主要阻断LTA4被白三烯A4水解酶LTA4H水解为LTB4。因此，可以用于制备治疗哮喘、系统性红斑狼疮、炎症、心肌梗塞、非小细胞肺癌、急性髓性白血病、实体瘤的药物。
摘要（英）：

The invention discloses cinnamylate lipoid substance and the application thereof in the preparation of leukotriene A4 hydrolytic enzyme functional regulating medicine. The general structural formula of the cinnamylate lipoid substance is that experiment proves that the cinnamylate lipoid substance has obvious function of leukotriene A4 hydrolytic enzyme functional regulator and mainly prevents LTA4 being hydrolyzed into LTB4 by leukotriene A4 hydrolytic enzyme LTA4H. Therefore, the cinnamylate lipoid substance can be used for preparing medicine for treating asthma, systemic lupus erythematosus, inflammation, miocardial infarction, non-small cell lung cancer, acute myelaid leukemia and solid tumor.

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