The invention discloses a quality control method for Kouyanqing granules, which comprises the following steps: preparing and mixing a reference substance solution; preparing a methanol solution of the Kouyanqing granules as a test solution; analyzing the reference substance solution and the test solution by a high performance liquid chromatography to obtain a high efficiency liquid chromatography finger print of the Kouyanqing granules; and comparing and monitoring the quality of the Kouyanqing granules according to a chromatogram map of the reference substance solution and a finger print of the test solution. The invention also discloses application of the quality control method in identifying the Kouyanqing granules. The quality control method adopts the high efficiency liquid chromatography to establish the finger print of the Kouyanqing granules, and can monitor the stability of technical processes for producing semi-finished products and finished products through the established standard finger print. The method effectively avoids counterfeiting of products, ensures normal production and circulation order of the products, and has outstanding practicability.