Re and Serial rare-earth borate laser glass has a chemical formula of ReBa3B9O18 (Re is a rare-earth element except for La and Ce) or Re (1-x) Re'xBa3B9O18 (x is large than zero and smaller than one; Re and Re' are rare-earth elements except for La and Ce), and the two rare-earth elements can be mixed mutually according to needs. The Serial rare-earth borate laser glass has simple manufacture process, high optical homogeneity, favorable mechanical and heat conduction performances and lower expansion factor, does not dissolve in water and deliquate, and is easy to process, and can also satisfy the requirement of any large size and is suitable for making working-laser material.