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发明授权
CN101524350B N-甲基-N-苄基-3-氯-6-甲氧基-苯并噻吩-2-甲酰胺的应用 失效 - 权利终止

N-甲基-N-苄基-3-氯-6-甲氧基-苯并噻吩-2-甲酰胺的应用
摘要：
本发明涉及医药技术领域。双特异性蛋白激酶Dyrk1A的基因被发现与唐氏综合征存在着紧密的联系，双特异性蛋白激酶目前已报道的抑制剂有EGCG、harmin、roscovitine、purvalanol等。本发明提供了N-甲基-N-苄基-3-氯-6-甲氧基-苯并噻吩-2-甲酰胺在制备双特异性蛋白激酶Dyrk1A抑制剂中的应用。N-甲基-N-苄基-3-氯-6-甲氧基-苯并噻吩-2-甲酰胺经过体外激酶活性实验，证明其有明显的抑制Dyrk1A的作用，抑制活性大于EGCG。
摘要（英）：

The invention relates to the medical technology field. Genes of bispecific protein kinase Dyrk1A are found closely related to Down syndrome. The presently reported inhibitors of the bispecific protein kinase comprise EGCG, harmin, roscovintine, purvalanol and the like. The invention provides application of N-methyl-N-benzyl-3-chloro-6-methoxyl-benzothiophene -2-formamide to preparing the inhibitors of the bispecific protein kinase. In vitro kinase activity tests prove that the N-methyl-N-benzyl-3-chloro-6-methoxyl-benzothiophene-2-formamide has obvious inhibition effect on the Dyrk1A, and theinhibition activity thereof is greater than that of the EGCG.

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