The invention relates to a method for activating ammonia leaching for high calcium-magnesium zinc oxide ore. The high calcium-magnesium zinc oxide ore is firstly crushed and wetly grinded, the content of the ore of which ore grinding fineness is less than 74mu m and accounts for 70 to 90 percent, ammonia and ammonium salt are added into the ore under normal pressure, the concentration of the total ammonia is 2 to 6 mol/L, the ratio of the liquid to solid is between 2 to 1 and 5 to 1, a fluorine-containing activating agent is added into the mixture, and the mixture is stirred and leached for 0.5 to 3 hours. Then, the stirred and leached ore slurry is subjected to solid-liquid separation to form leachate and leached residue. The result shows that the addition of the activating agent can improve the zinc leaching rate by 3 to 5 percent. By adding the fluorine-containing activating agent HF as an activating agent, the property of the zinc ore which is difficult to leach is changed, the ammonia dissolution of the zinc is promoted, and the aim of improving the leaching rate of the zinc in the zinc oxide ore is achieved.