The invention relates to a marshalling station comprehensive automatic system, which comprises a comprehensive management subsystem, a centralized control subsystem and a process control subsystem. The comprehensive management subsystem uses a flow allocation table to exchange traffic flow information with a road bureau planning and dispatching system to jointly determine a departure plan with the road bureau planning and dispatching system, decomposes a plan assigned by a road bureau dispatching station into working plans of stations, and instructs the transport and production of the whole marshalling station in a way of the technical operation graphs and locomotive routing maps; the centralized control subsystem prearranges routes for trains and locomotives according to operation instructions obtained by discomposing the working plans assigned by the comprehensive management subsystem and feeds the instruction execution results back to the comprehensive management subsystem; and theprocess control subsystem receives departure, decomposition, marshalling, vehicle taking-out and placing or leading locomotive warehouse entering and leaving operations and feeds the instruction execution results back to the centralized control subsystem. The invention provides a marshalling station comprehensive automatic system, which is integral, highly efficient, stable and intelligent and can be widely used in a railway marshalling station system.