The invention discloses a waste-removing device applied in the process of producing large transfusion soft bag, relating to the field of drug production packing machinery. The device comprises a mounting wallboard 23 including an upper straight line drive unit mounting plate 1, an upper straight line drive unit 2, an upper connection plate 3, an upper pressure lever 4, a guide rod 21, a guide rodpressure spring 20, an upshooting waste component of an upper pressure plate 19 and an undershooting waste component comprising a lower pressure plate 17, an equal-height column 14, a lower connectionplate 16, a lower pressure lever 7, a lower pressure lever pressure spring 8, a lower straight line drive unit 10 and a lower straight line drive unit mounting plate 11; the device of the invention has the characteristics of simple structure, concise movement, stable operation and simultaneous removal of front and back waste angles; applied to the production line of the large transfusion soft bags, the device of the invention can be suitable for waste removal in the process of producing large transfusion soft bags of different specifications: the small one, the medium-sized one and the small-sized one; in addition, the device can be applied to production of large pharmaceutical factories and preparation rooms of various hospitals.