The invention relates to a protective sleeve with the cleaning function, which is used for accommodating and cleaning a portable electronic device and comprises a hollow body and a cover, wherein the body is provided with an opening; and the cover is arranged at one end of the opening and can cover the opening after being turned down. The protective sleeve also comprises a cleaning unit arranged in the body, wherein the cleaning unit comprises at least one cleaning roller which is fixed in the body through a rotating shaft and can rotate around the rotating shaft; and the cleaning roller is used for contacting the surface of the portable electronic device and rolling to clean the surface of the portable electronic device when the portable electronic device is accommodated into the body or taken out from the from the opening. The invention also provides a portable electronic device assembly.