The invention discloses an andrographolidume composition and application thereof. The composition consists of a component I and a component II according to a molar ratio of between 1:10 and 10:1, wherein the component I is at least one of andrographolidume, andrographolidume derivatives and pharmaceutically acceptable salts of the andrographolidume derivatives, and the component II is at least one of lipoic acid and dihydrolipoic acid. The composition can be prepared into anticancer, anti-inflammatory, antibacterial, antivirus or hypoglycemic medicaments.