The invention discloses a validamycin amphiphilic polymer network and a synthesis method thereof. The validamycin amphiphilic polymer network is obtained by a chemical reaction of validamycin and hydrophobic polymer containing CH2Cl active group and swelled by a sweller, and the polymer network contains hydrophilic hydroxyl groups and hydrophobic benzene rings. The method has simple steps; the synthesized validamycin amphiphilic polymer network contains mass hydrophilic hydroxyl groups and hydrophobic benzene rings and can be swelled in different phases, which allows the Jinggangmeisu to be applied more widely.