The invention discloses a preparation method of cinepazide maleate, comprising the steps of (1) preparing 1-piperazine acetyl pyrrolidine (IV) and (2) taking 1-piperazine acetyl pyrrolidine as material to prepare cinepazide maleate. The preparation method of 1-piperazine acetyl pyrrolidine comprises the following steps: placing piperazine dihydrochloride in water to react with alkaline and obtaining a reaction system containing piperazine monohydrochloride; (2) adding chloracetyl pyrrolidine into the reaction system for reaction, adjusting pH to 10-13 by using alkaline material, collecting 1-piperazine acetyl pyrrolidine from reaction products. The method for preparing the cinepazide maleate has low cost, high material utilization ratio, simple and convenient operation and higher yield and is suitable for industrial production.