The invention provides a guide mechanism for a storage box of a refrigerator, which is a mechanism for guiding the storage box of the refrigerator. The guide mechanism for a storage box of a refrigerator comprises a first guide mechanism, and the first guide mechanism is provided with a pair of guide parts and matching parts which correspond to the guide parts, wherein the guide parts are positioned on the upper surface of a separating plate for supporting the storage box; and the matching parts are positioned on the lower surface of the storage box of the refrigerator and matched with the guide parts. When the storage box is pushed and pulled, the storage box can slide in a way that the matching parts move along the guide parts, thereby smoothly pushing and pulling the storage box. The storage box can be prevented from swaying along the left direction and the right direction by the abutting between the matching parts and the guide parts, therefore, the guide mechanism for a storage box of a refrigerator can smoothly push and pull the storage box by a simple structure, prevent the storage box swaying left and right and improve the reliability and the comfort level of use.