The invention discloses a pawpaw nutritional effervescence tablet and a preparation method thereof. The pawpaw nutritional effervescence tablet comprises the following components according to parts by weight: 20 to 80 parts of pawpaw extracting liquid, 5 to 30 parts of vitamin C, 5 to 20 parts of citric acid, 5 to 20 parts of malic acid, 20 to 50 parts of sodium bicarbonate, 5 to 40 parts of dextrin, 1 to 10 parts of polyvidone, 3 to 10 parts of polyethylene glycol, 0.1 to 5 parts of aspartame, 0.1 to 5 parts of microcrystalline cellulose, 0.1 to 5 parts of sodium carboxymethylcellulose and 0.1 to 5 parts of L-leucine; the pawpaw extracting liquid is obtained in such a way that pawpaw after being denucleated and sliced is added with water, ground, pulped, then added with enzymes for hydrolyzing and filtering, and filter liquor is concentrated; the preparation method of the effervescence tablet comprises the following steps: firstly, the pawpaw extracting liquid, the vitamin C, the citric acid, the malic acid, the dextrin and the polyvidone are prepared into acid particles; then, the sodium bicarbonate and the polyethylene glycol are prepared into alkaline particles; finally, the two particles and the rest components are evenly mixed and tabletted to obtain the pawpaw nutritional effervescence tablet; and the effervescence tablet has obvious antioxidation activity, quick disintegration and good mouth feel.