The invention provides a method for producing a blue-ear disease vaccine by culturing a sensitive cell. The method comprises the following steps: 1) culturing the sensitive cell on a microcarrier in a bioreactor; 2) inoculating a porcine reproductive and respiratory syndrome virus to the sensitive cell cultured on the microcarrier; 3) continuously culturing the sensitive cell; and 4) obtaining virus solution to produce the blue-ear disease vaccine. The method produces the blue-ear disease vaccine by culturing the sensitive cell in the bioreactor by applying microcarrier culture technology. The microcarrier provides larger surface area, the cell can reproduce to generate higher cell density, and automatically controlled culture environment parameters of the bioreactor ensure that the cell growth and virus propagation can be in an excellent environment, so the method can improve the virus titer, and ensures more stable vaccine quality.