The invention discloses an enhanced polybutylene terephthalate flame-retardant heat conduction material preparation method, comprising the following steps: adding polybutylene terephthalate and processing agent in a high effective mixer to mix, then adding composite flame retardant, flame-retardant synergist, nanometer heat conducting agent, flexibilizer, antioxidant and stabilizer in the mixer, mixing the materials evenly, then adding the mixture in a double-screw extruder through a main charging hole, adding glass fibre in the double-screw extruder to extrude the material and finally obtaining the conduction material after water-cooling and dicing. The conduction material not only has excellent thermal conductivity, fire resistance and mechanical properties, but also solves the heat dissipation problem caused by electronic and electrical product miniaturization brought by the technical progress.