The invention relates to a portable and easily-held handheld wireless mouse, comprising a mouse shell and a central controller. The back of the mouse shell is provided with a handheld part, the handheld part is provided with an accommodating chamber, the front of the mouse shell is provided with a direction operating mechanism for controlling a moving direction of the mouse, and the direction operating mechanism is connected with a direction sensing module of the central controller; a click key is arranged on one side of the mouse shell, and the click key is connected with a click sensing module of the central controller; the central controller also comprises a signal processing module, a buffering module and a sending module, and a receiving module for receiving data from a sending module is arranged in a computer; the direction operating mechanism comprises a potentiometer and an operating lever connected with a movable contact of the potentiometer, the potentiometer is connected with the direction sensing module capable of sensing a potential signal output by the potentiometer, and the direction sensing module is connected with a signal processing module identifying the potential signal into the moving direction. The invention has the advantages of adjustable movement speed of the mouse according to requirements, low cost and low energy consumption.