The invention provides a three-point calibration method based on a nonuniform touch screen, which aims to establish the mapping relation between a touch screen coordinate and a display screen coordinate and comprises the following steps: 10, dividing the nonuniform touch screen into a plurality of areas; 20, selecting three sampling points in each area to perform three-point calibration so as to obtain the mapping relation between the touch screen coordinate and the display screen coordinate in each area; 30, calculating the coordinate of a center point in each area according to the coordinates of the three sampling points, wherein the coordinate of the center point is the average coordinate of the three sampling points; and 40, determining the coordinate of the central point closest to the touch screen coordinate so that the touch screen coordinate conforms to the mapping relation of the area of the center point. The method adopts divided areas to perform the three-point calibration to obtain the mapping relation of each area, and then distinguishes the touch screen points of each area according to a principle of 'being closest to the center point', so the calibration result is more precise.