The invention provides a method for synthesizing multi-substituted 1-naphthol. At 140 DEG C or 160 DEG C, dimethylbenzene or 1,3,5-trimethylbenzene is used as a solvent, and zincon and a raw materialof 2,3-allenoic acid ester have a 1,4-addition reaction and an intramolecular cyclization reaction to obtain a series of multi-substituted 1-naphthol compounds, wherein the zincon and the 2,3-allenoicacid ester firstly have a 1,4-addition reaction to generate a 1,3-conjugated diene zinc oxide salt; then an intramolecular Friedel-Crafts reaction is carried out to obtain a 1-naphthol zinc oxide salt; and a decomposition reaction is carried out to obtain the 1-naphthol. The method does not need a catalyst for the reactions and has simple operation and easy obtaining of the raw material and reagents. Three substituent groups can be simultaneously introduced on the 1-naphthol, and a product is easy to separate and purify, thus the method is suitable for synthesizing various kinds of the multi-substituted 1-naphthol.