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发明公开
CN101638393A 一种新型血管紧张素Ⅱ的1型受体拮抗剂的制备及其降血压、抗肿瘤等应用 无效 - 撤回

一种新型血管紧张素Ⅱ的1型受体拮抗剂的制备及其降血压、抗肿瘤等应用
摘要：
本发明公开了一种新型氨基酸联苯化合物，该化合物是由联苯与氨基酸、噁二唑有机地连接起来而成，是血管紧张素II的1型受体拮抗剂，该化合物可用于制备预防或治疗高血压、冠心病、心脑肾血管疾病、偏头痛、肺动脉高压等疾病的药物，也可以有效地抑制原位癌，如胃癌、胰腺癌、卵巢癌、前列腺癌、肺癌、膀胱癌、肝癌、肾癌、乳腺癌、宫颈癌、结肠癌等的增殖、迁移。
摘要（英）：

The invention discloses a novel phenylaniline compound which is formed by organically connecting biphenyl with amino acid and oxadiazole and is the 1-type receptor antagonist of a novel hypertension II. The compound can be used for preparing medicines for preventing or treating diseases, such as high blood pressure, coronary heart disease, cardio-cerebral renovascular disease, splitting headache,splitting headache, and the like and can be used for effectively inhibiting the multiplication and the mobility of carcinomas in situ, such as gastric cancer, pancreatic cancer, oophoroma, prostatic cancer, lung cancer, bladder cancer, liver cancer, renal carcinoma, breast cancer, cervical carcinoma, colon carcinoma, and the like.

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