The invention provides a human-porcine reassorted rotavirus, and aims to solve the technical problem that attenuated vaccine from animal genes is used for preventing related diseases of human. A porcine rotavirus is unique in rotaviruses of mammal and birds, and has a special relationship with a human rotavirus. The invention has the key points that: a gottfried strain of the porcine rotavirus with unique nature, particularly the gottfried strain of which the serotype is P[6], G4 is adopted, immune components at least comprise a rotavirus reasserted strain; and each rotavirus reasserted strainat least comprises a gene for coding a protein which generates cross reaction with the serotype of the human, and a gene for coding a protein of the Gottfried strain of the porcine rotavirus is at least reserved. The human-porcine reassorted rotavirus has the following function: a monovalent reasserted animal rotavirus and a human rotavirus or other animal virus capable of generating the cross reaction with antigen of the human are combined to provide one of serotypes with the closest relationship with the clinical study of A group of the human rotavirus so as to induce to generate human rotavirus specific antibody reaction.