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发明公开
CN101643732A 在乳腺癌和膀胱癌中差异表达的基因及编码的多肽 无效 - 撤回

在乳腺癌和膀胱癌中差异表达的基因及编码的多肽
摘要：
本发明涉及在人类癌症中差异表达的新的人基因。更具体而言，本发明涉及编码在人乳腺癌和膀胱癌中过表达的、称为C35的新的人多肽的多核苷酸。本发明还涉及C35多肽及其载体、宿主细胞、C35多肽的抗体，及其重组制备方法。本发明进一步涉及检测癌的诊断方法，包括人乳腺癌。本发明另外涉及C35基因及多肽在免疫原性组合物或疫苗中的组成和应用，以诱导针对表达C35基因的靶细胞(例如肿瘤细胞)抗体或细胞介导的免疫。本发明还涉及鉴定C35活性的激动剂和拮抗剂的筛选方法。蛋白质序列MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPY EKDLIEAIRRASNGETLEKITNSRPPCVIL*
摘要（英）：

The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptides, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.

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