he present invention provides a data detection for codes with non-uniform spreading factors. A plurality of communication signals is received. Each communication signal has an associated code. At least two of the communication signals has a different spreading factor. The associated codes have a scrambling code period. A total system response matrix has blocks. Each block has one dimension of a length M and another dimension of a length based on in part M and the spreading factor of each communication. M is based on the scrambling code period. Data of the received plurality of communication signals is received using the constructed system response matrix.