The invention provides an inter-domain prefix hijacking detection method for error configuration in a network system which at least comprises one autonomous system; the autonomous system comprises a monitoring probe which comprises a network prefix information list for storing prefix information in the autonomous system; the method comprises the following steps: the monitoring probe obtains a routing update message which is transmitted outwards by the autonomous system; all items of the routing update message is analyzed, and the item for adding types carries out the next step, and the items which exist in the network prefix information list and have completely consistent prefix information are not operated additionally, and the next item in the routing update message is directly processed; for the items which do not exist in the network prefix information list or although the items exist in the network prefix information list, the prefix information is conflicted, the validity of theitems is actively detected; the network prefix information list is updated according to the verified items for adding types. The method can avoid error configuration and maintain network safety.