The invention discloses a system for completing sequential control by intelligent one-key operation. The system consists of an operator station of a station monitor and control layer, intelligent equipment of a bay layer, and an intelligent interface of a process layer; and the control process comprises that: a sequential control instruction is selected manually on the operator station of the station monitor and control layer through a mouse or a key, and is transmitted to a device of the bay layer through an Ethernet; after receiving a sequential control command of a background machine, the intelligent equipment of the bay layer independently performs sequential control, and adopts GOOSE mechanism-based logic interlock judgment to realize misoperation prevention; and a network of the process layer and the intelligent interface of the process layer perform information interaction of a tripping command and a position state, and the interactive mechanism is based on a GOOSE mechanism. The system has clear hierarchies; and the GOOSE mechanism ensures quick and reliable information transmission, and the sequential control ensures high efficiency and reliability of switching operation.