The invention discloses a liquid based cell preservative fluid which is used for matching with an imported or home-made film type liquid based cell film making machine for making films and belongs to the technical field of medicaments. The liquid based cell preservative fluid basically consists of the following components according to the ratios by volume: 10-30 percent of alcohols and the balance of double distilled water; the liquid based cell preservative fluid comprises the following components with the concentration expressed in percentage by mass/volume: 0.1-3.0 percent of phosphate, 0.1-2.0 percent of phenol and 0.1-2.0 percent of N-methyl-N-cyclohexyl-2-amino-3, 5-dibromobenzylamine. Firstly, the invention uses an ordinary biochemical reagent, and the price of consumptive materials is reduced in comparison with the cell preservative fluid produced by an imported auxiliary consumptive material Thinprer TCT. Secondly, because the N-methyl-N-cyclohexyl-2-amino-3, 5-dibromobenzylamine as a unique mucus decomposer is used, the cells wrapped by the mucus in a sample can be successfully separated, avoiding the accumulation and loss of positive cells. Smears prepared by using the liquid based cell preservative fluid to match with an automatic film making machine have clear and transparent backgrounds and uniformly distributed cell monolayers, and are convenient for the film reading of doctors in a pathology department.