The invention discloses an image sharpening method for TFT-LCD color display. Taking adjacent five pixel points in a row as a processing unit, the image sharpening method can reduce the storage capacity and the calculation amount, is particularly suitable for color display of a small-size TFT-LCD and easy to be realized in a singlechip-integrated TFT-LCD drive control chip. The visual characteristic of human eyes is considered, sharpening factors are calculated according to the gray value of pixel points, and the image sharpening noise is reduced. By adopting zoom factors and different sharpening strengths aiming at five image areas with the gray changing from the flatness to the sharpness, the invention better solves the problem of the gray value overflow; and by using an energy dispersion filter, the invention obviously improves the color distortion phenomenon of sharpened images.