The invention relates to uron medicinal liquor for activating blood, eliminating dampness and removing spur and a preparation method thereof, aiming at solving the problems of unobvious effect of treating both the symptoms and root causes of the disease, long treatment cycle, easy recurrence, worsening the disease state after recurrence and the like in the prior art. The medicinal liquor belongs to traditional Chinese medicine preparation of oral medicinal liquor for treating hyperosteogeny (including osteophyte and proliferative or hypertrophic arthritis) caused by rheumatism and sprain. Themedicinal liquor has scientific and reasonable compatibility of all medicines, unique preparation method and remarkable efficacy, and can be used for treating various osteophyte diseases (such as cervical spondylosis hyperosteogeny, lumbar vertebra hyperosteogeny, knee-joint hyperosteogeny, hip-joint hyperosteogeny, elbow-joint hyperosteogeny, calcaneal hyperosteogeny, metatarsus hyperosteogeny and the like) caused by the rheumatism and the sprain. The clinical application of 43 patients proves that the uron medicinal liquor has short treatment cycle, rapid effect, no rebound and exact curative effect, achieves the effect of treating both the symptoms and root causes of the disease, and can be clinically applied, thus being worth popularization.