The invention belongs to the seepage-proofing technology field and in particular discloses a seepage-proofing processing method of a canal concrete panel crack; by taking the crack as a central line, a concrete panel crack is ground into a groove on site, an isolation layer is adhered or coated on the inseam surface of the groove, primer is coated on the inner surface of groove at two sides of the isolation layer, and then elastic seepage-proofing material is filled until the seepage-proofing material is leveled with the panel. The seepage-proofing processing method has the beneficial effects that: (1) the concrete for canal lining is C15-C30, an angle grinder is used to grind the groove easily; (2) the isolation layer is adhered or coated on the inseam surface of the groove, so as to be beneficial to leading material to be deformed with the seam; (3) high-intensity high-elongation elastic material is filled in the crack to meet water pressure function and to be adaptive to the deformation of the crack; (4)the primer is coated to improve the adhering and sealing effect of the elastic material and the concrete polished surface and current scouring and stripping resistant capacity; (5) the seepage-proofing material is leveled with the canal panel, so as to reduce the stripping function of the water current to the material, and the seepage-proofing material is leveled can not block water; (6) the construction speed is rapid and the manufacturing cost is low; (7) the method is suitable for impounding reservoir and sewage pool engineering and the like.