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发明授权
CN101703778B 一种基于MCM-41的释药载体及其制备方法 失效 - 权利终止

一种基于MCM-41的释药载体及其制备方法
摘要：
一种基于MCM-41的释药载体及其制备方法。该释药载体是由MCM-41和PAA复合的其含水率不高于1.0％的凝胶状的复合材料MCM-41-PAA，其中，MCM-41与PAA的质量比为1∶4。其制备方法按照合成PAA(聚丙烯酸)凝胶及其在复合材料MCM-41-PAA中的比例加入丙烯酸，并据此加入引发剂，交联剂，蒸馏水和乙醇，通氮赶氧后，在30℃下恒温聚合24h并纯化得复合材料。本发明不仅使得载药量大大的提高，还可以根据pH控制释药，克服了单纯MCM-41的无响应和单纯凝胶载药量的不足，使得药物利用率和可控性都大大提高，提高治疗效果。
摘要（英）：

The invention discloses an MCM-41-based drug releasing carrier and a preparation method thereof. The drug releasing carrier is a gelatinous composite material MCM-41-PAA which is compounded by MCM-41 and PAA and has the water content of not more than 1.0%, wherein the mass ratio of the MCM-41 to the PAA is 1:4. The preparation method thereof comprises the following steps: according to the composite PAA (polyacrylic acid) gel and the ratio thereof in the composite material MCM-41-PAA, adding acrylic acid, adding an initiator, a cross linker, distilled water and alcohol, introducing nitrogen and removing oxygen, then polymerizing for 24h under the constant temperature of 30 DEG C, purifying and obtaining the composite material. The invention not only improves the drug loading rate greatly, but also overcomes the defect the non-response of the pure MCM-41 and pure gel drug loading rate, thus leading the utilization ratio and controllability of drugs to be improved greatly, and improving the treatment effect.

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