The invention discloses a device and a method for removing various pollutants simultaneously by lime stone-gypsum wet process. The device comprises an absorption liquid seriflux pot, a booster fan, a spray tower and the like, strong oxidizing agent and efficient absorbent are mixed to prepare absorption liquid desulfurated by wet process, fume with motive power supplemented by the booster fan enters into the spray tower, the upper middle part of the spray tower is provided with 2-4 layers of spray layers for spraying the absorption liquid into the spray tower so that the absorption liquid and the fume contact well, and the absorption liquid in the liquid storing tank can be used circularly under the action of an absorption liquid circulation pump. The upper part of the spray layers is provided with a demister for removing the water vapor in the fume, and the fume demisted by the demister is exhausted from the top of the spray tower to be out of the chimney. The invention has the following advantages: 1) simultaneous removal of various pollutants can be realized by only one lime stone-gypsum process technology; 2) selectable oxidizing agent varieties are plentiful; and 3) the removal efficiency of the pollutants is high.